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Glaxo Experimental Drug Shows Promise In Study

Posted by Chrissie Cole
Wednesday, November 05, 2008 3:32 PM EST
Category: Major Medical
Tags: FDA and Prescription Drugs, Sirtris Pharmaceuticals, GlaxoSmithKline, Healthy Living, Weight Loss, Obesity, Diabetes, Resveratrol

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IMAGE SOURCE:© Wikimedia Commons/ red wine/ author: Andre Karwath

An experimental drug that imitates a health-boosting compound found in red wine may offer promise in the fight against diabetes and obesity, according to researchers.

A study showed that GlaxoSmithKline’s drug SRT1720, which targets the SIRT1 gene, was a thousand times more effective than resveratrol in activating an enzyme that helped mice to burn more energy while lowering insulin and glucose levels.

The drug also helped lower cholesterol levels and the mice lost a reasonable amount of weight compared to the mice given a placebo.

Red wine is a good source of resveratrol, as is the crust of peanuts and walnuts.

"Resveratrol makes mice live longer and stay healthier," Peter Elliott, a vice president at Sirtris Pharmaceuticals. "This molecule does the same thing, but it is 1,000 times more potent so not as much is needed."

The study found mice fed a high daily dose of the experimental drug over a period of three months didn’t gain weight while on a high-fat diet. However, lower doses of the drug were not effective.

The mice were fooled into switching their metabolisms to fat-burning mode that usually takes over when energy levels are low.

"Essentially, we are activating similar enzymes as the ones activated when people go to the gym," said Elliott.

While on the high-dose of the drug, mice also gained strength and endurance and they didn’t develop insulin resistance, a condition that precedes type 2 diabetes.

Phase I trial found the drug safe and well-tolerated. The company is planning to start a larger Phase II trial with diabetics in 2009.

The drug has been tested on mice only so far. It will be quite some time before SRT1720 will be available for humans. But there is a low-tech, good old fashion way of preventing weight gain that will also benefit the brain, heart, and rest of the body – the timeless and true combination of a healthy diet coupled with moderate exercise.

The study is published in the journal Cell Metabolism. #


1 Comment

Anonymous User
Posted by Futurespeak
Thursday, November 06, 2008 11:32 AM EST

Resveratrol can help you to lead a long and healthy life so says Dr. Oz.
Red wine alone does not supply enough resveratrol to achieve the
full range of benefits because one glass of red wine has only about
1mg of resveratrol and you need about 250mg/day. You need to take
high potency resveratrol supplements to achieve the results documented
in scientific studies.Resveratrol Supplements can also help you control
your weight naturally by increasing energy, reducing cravings, and limiting
your appetite.According to Wikipedia, Consumer Lab, an independent dietary
supplement and over the counter products evaluation organization,
published a report on 13 November 2007 on the popular resveratrol
supplements. The organization reported that there exists a wide range
in quality, dose, and price among the 13 resveratrol products
evaluated. The actual amount of resveratrol contained in the
different brands range from 2.2mg for Revatrol, which claimed to have
400mg of "Red Wine Grape Complex", to 500mg for Biotivia.com Transmax,
which is consistent with the amount claimed on the product's label.
Prices per 100mg of resveratrol ranged from less than $.30 for
products made by Biotivia.com, jarrow, and country life, to a high of
$45.27 for the Revatrol brand.

Comments for this article are closed.

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