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FDA Warning about Bed-Wetting Drug

Posted by Jane Akre
Monday, December 10, 2007 2:32 PM EST
Category: Major Medical
Tags: Defective Drugs

FDA is warning against using desmopressin for bed wetting because of a possible link to seizures

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The FDA is warning against using a bed-wetting drug, desmopressin because of a possible link to fatal seizures that have left two dead.

The agency is no longer approving desmopressin be used as a nasal spray to control bed-wetting in children.

The agency says children using the nasal spray are more likely to develop severe hyponatremia which is a dangerously level of low sodium in the blood which can trigger seizures and even death.

The prescription drug is given to limit the quantity of water eliminated in the urine. Desmopressin controls the urge to drink and to urinate and is used to prevent dehydration that can be caused by surgery, an injury or even diabetes.

Taking the drug allows you to sleep through the night without having to urinate.

A healthy body needs to balance water and salt (sodium). The drug not only increases the chance of a water and sodium imbalance but increased complications can result if the patient is taking other medications such as antidepressants, or during hot weather when they may become thirsty, or if they have a fever, severe vomiting or a cold.

Desmopressin also comes in a tablet form and the FDA warns that form of the drug “should be used cautiously” during time of excess fluid intake including a fever or vomiting because of the danger that electrolytes can become imbalanced.

So far the FDA has received 61 adverse events reports of seizures and two deaths among patients ages 80 and 28.

However a direct link of desmopressin to the deaths has not been established. "The direct contribution of desmopressin to the deaths is unclear," the FDA said in a notice.

The synthetic drug has several manufacturers but is known as DDAVP, DDVP, Minirin and Stimate Nasal Spray. 

The FDA is asking that the prescribing information be updated by the manufacturers.

Desmopressin does not cure bed-wetting. Most children, 50 to 90 percent relapse after the drug is stopped.


1 Comment

Anonymous User
Posted by Enuresis Treatment Center
Wednesday, December 12, 2007 10:07 AM EST

We came across your blog posting, and would like to advise that drugs do not address the root cause of bedwetting: A deep sleep disorder. If pills and nasal sprays are being used and show some effectiveness, once the drugs are discontinued, the bedwetting will resume. They are merely a temporary fix, and have many side effects. For 32 years, the Enuresis Treatment Center has successfully treated thousands of people from around the world by establishing a new and healthy pattern of sleep. The Enuresis Treatment Center cures bedwetting without the use of drugs. Physicians bring their own children for treatment instead of subjecting them to drugs. The Enuresis Treatment Center has put together an informative guide to understanding and treating bedwetting. This free bedwetting guide is available to download at LINK

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