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Diabetes and Anti-Aging Drug Has Roots in Wine

Posted by Jane Akre
Tuesday, January 08, 2008 9:46 PM EST
Category: Major Medical, Protecting Your Family
Tags: Medical Devices, FDA and Prescription Drugs


Resveratrol found in the red grape, is the central ingredient in drugs being developed to fight diabetes and age related disease.


Baby Boomers are always looking for ways to stop the aging process and scientists are there to fill the void. 

The latest new compound comes from the red wine ingredient resveratrol and may be helpful in fighting age related diseases and type 2 diabetes. The results were announced Monday by Sirtris Pharmaceuticals at the J. P. Morgan Healthcare Conference in San Francisco. 

Resveratrol is found in red wine and in grapes and is a natural defense mechanism against bacteria and pathogens.  The compound stimulates a gene known as SIRT1 in rodents that has translated into an expanded lifespan when given in doses larger than found in nature. 

The company believes the drug works on the symptoms of aging by targeting the gene that controls aging.  SIRT1 was discovered by Sirtris co-founded David Sinclair of Harvard Medical School who has shown that animals live longer when SIRT1is stimulated through a calorie-restricted diet.  Resveratrol stimulates the same gene without the starving. Sinclair himself began taking the over-the-counter supplement.   

At an investor conference in San Francisco Monday, Sirtris released the results of the first phase of a diabetic research trial involving 98 patients.  67 diabetics got a daily dose of resveratrol. 31 others received a placebo in the study conducted in India. 

After the first month, diabetics on resveratrol had improved their body’s ability to break down sugars.  People with type 2 diabetes do not effectively use insulin that helps convert sugars into energy. The placebo patients did not show an improvement. The first phase of any trial is generally to determine safety rather than efficacy.

No side effects were reported. 

Sirtris, a Cambridge, Massachusetts company, is working on several disease fighting drugs including a similar compound that is 1,000 times more potent than resveratrol. Don't expect anything on the market before 2012.

Sirtris Pharmaceuticals went public in May 2007. Since then it’s up 23 percent. Shares jumped $1.41 to $14.60 in aftermarket activity Monday.  #





Anonymous User
Posted by Jane Rutledge
Wednesday, January 09, 2008 11:36 AM EST

I have been taking resveratrol for 6 months from biotivia bioforte and the results have been amazing.
The first month I did not notice any changes but since then I have had much greater energy throughout the day, less appetitie so I am losing weight, and I have been sleeping sraight through the night. My quality of life has improved dramatically. Now I learn that there are possible anti-aging benefits and possibly anti-cancer and anti-diabetes effects as well.This is icing on the cake

Posted by Anthony Loera
Wednesday, January 09, 2008 1:07 PM EST

Here is a public forum with a price watch list containing over 80 resveratrol products for you to compare prices on:


You can find exactly what you are looking for and ask questions.


Comments for this article are closed.

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